SYNTHESIS AND PROPERTIES OF SOME 4- (4-HYDROXY-PHENYL) -2-METHYL-6- THIOXO-1,5-DIHYDRO-PYRIMIDINE-3-CYCLIC THIOUREAS

Abstract

4-(4-hydroxy-phenyl)-2-methyl-6-thioxo-1,5-dihydro-pyridine-3-cyclic thioureas were synthesized on the basis of three-component condensation of ethyl ether of salicyl aldehyde and acetoacetic acid with thiourea. The simplest and most convenient way to synthesize cyclic thioureas is the single-stage three-component condensation of aldehydes, methylene active compounds and
thiourea in an acidic environment. The synthesized compounds are crystalline substances. These compounds have the ability to exhibit antioxidant properties due to the presence of thiourea fragment.