LARGE CATTLE CORONAVIRUS: EPIZOOTIC STATUS, GENOME STRUCTURE, CLINICAL SYMPTOMS AND PREVENTION-MINI REVIEW

Abstract

Bovine diarrhea is of multifactorial origin, causing heavy mortality risk and having a negative impact on animal welfare along with high economic loss in animal husbandry. Coronoviruses are one of the main enteropathogenic viruses of humans and newborn calves. A review of the available data indicates that further research is needed to understand the underlying pathogenesis mechanisms of BCoV respiratory and intestinal diseases, as well as the variables and interactions between the virus, host, and environmental factors that can exacerbate the disease or lead to increased spread and transmission. Further extensive research is needed to determine the correlates and attributes of immune defense needed to develop effective vaccines/regimens that can
prevent severe disease and limit the spread of the virus.